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| DC Element | Wert | Sprache |
|---|---|---|
| Autor*in | Belstrøm, Daniel | - |
| Autor*in | Olsen, Jesper V. | - |
| Autor*in | Cappellini, Enrico | - |
| Autor*in | Jensen, Lars J. | - |
| Autor*in | Willerslev, Eske | - |
| Autor*in | Fotakis, Anna K. | - |
| Autor*in | Kelstrup, Christian D. | - |
| Autor*in | Lynnerup, Niels | - |
| Autor*in | Jersie-Christensen, Rosa R. | - |
| Autor*in | Lanigan, Liam T. | - |
| Autor*in | Lyon, David | - |
| Autor*in | Mackie, Meaghan | - |
| Datum | 2018 | - |
| Quelle | https://doi.org/10.1038/s41467-018-07148-3 | - |
| Quelle | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246597/ | - |
| Quelle | http://www.ncbi.nlm.nih.gov/pubmed/30459334 | - |
| URI | https://www.amad.org/jspui/handle/123456789/74126 | - |
| Beschreibung | The composition of ancient oral microbiomes has recently become accessible owing to advanced biomolecular methods such as metagenomics and metaproteomics, but the utility of metaproteomics for such analyses is less explored. Here, we use quantitative metaproteomics to characterize the dental calculus associated with the remains of 21 humans retrieved during the archeological excavation of the medieval (ca. 1100–1450 CE) cemetery of Tjærby, Denmark. We identify 3671 protein groups, covering 220 bacterial species and 81 genera across all medieval samples. The metaproteome profiles of bacterial and human proteins suggest two distinct groups of archeological remains corresponding to health-predisposed and oral disease-susceptible individuals, which is supported by comparison to the calculus metaproteomes of healthy living individuals. Notably, the groupings identified by metaproteomics are not apparent from the bioarchaeological analysis, illustrating that quantitative metaproteomics has the potential to provide additional levels of molecular information about the oral health status of individuals from archeological contexts. | - |
| Sprache | eng | - |
| Rechte | © The Author(s) 2018 ; Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | - |
| Schlagwörter | Article | - |
| Dewey-Dezimalklassifikation | 940 | - |
| Titel | Quantitative metaproteomics of medieval dental calculus reveals individual oral health status | - |
| Typ | Text | - |
| AMAD ID | 573949 | - |
| Jahr | 2018 | - |
| Open Access | 1 | - |
| Enthalten in den Sammlungen: | BASE (Bielefeld Academic Search Engine) General history of Europe | |
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